Figure 4 - full size

 

Figure 4.
Figure 4. Diagrammatic illustration of the interactions formed by the ligands bound in the active sites of DspB (a) and 1HP5 (b). The hydrogen bond interactions are indicated with a broken line. An arc with radiating lines represents the hydrophobic interactions in the structure. The glycerol is labeled as Gol. (c) Superposition of active site residues at subsite -1 of 1HP5 (magenta) with the corresponding residue from DspB (green). Note that the residues in both the enzymes are almost conserved. Note also the absence of the Trp408 residue in DspB and the difference in the loop conformation and length in DspB.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2005, 349, 475-486) copyright 2005.