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Figure 4.
FIG. 4. Structural comparison of E. coli AstB with a
representative amidinotransferase. a, the active site residues
of the AstB C365S mutant with the N-succinylarginine substrate.
In this figure Ser365 was replaced by the native Cys365 taken
from the native structure. The oxygen atoms are red, nitrogen
atoms are blue, sulfur atoms are yellow, and carbon atoms are
gray. The hydrogen bonds between the ligand and protein atoms
are marked by green dashed lines. b, the active site of arginine
deaminase (Protein Data Bank codes 1LXY [PDB]
or 1S9R) with the reaction product in a similar orientation to
that shown in a.
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