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Figure 4.
Figure 4. Model for catalysis by class III nucleotidyl cyclases.
The model for catalysis (bottom pathway) is based on the
conformational changes observed with the sAC -substrate analog
complexes (top). The arrows at  1
and  7
- 8
indicate the movements undergone by these protein parts. The
individual catalytic states (open, intermediate and closed) are
extrapolated from the different sAC structures presented in the
text, with the protein conformation of the sAC -Rp-ATP S
complex being a speculative approximate intermediate state.
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