Figure 4.
FIG. 4. A, binding of Gleevec to Syk. Ligand difference
electron density (2 F[observed]-F[calculated]) contoured at 1
.
B, binding of Gleevec and staurosporine to Syk. Gleevec (yellow)
binding to Syk in the compact cis-conformation mimics the
structure and binding mode of staurosporine (salmon). The key
residues are labeled, and hydrogen bonds are denoted with dashed
lines. The images were prepared with Xfit (25).
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2004,
279,
55827-55832)
copyright 2004.
.
B, binding of Gleevec and staurosporine to Syk. Gleevec (yellow)
binding to Syk in the compact cis-conformation mimics the
structure and binding mode of staurosporine (salmon). The key
residues are labeled, and hydrogen bonds are denoted with dashed
lines. The images were prepared with Xfit (25).