Figure 4.
FIG. 4. Structural changes of Neu2 upon maltose and DANA
binding. a, ribbon diagram of Neu2 apo form, viewed from the
side. The active site is located on the top part of the protein.
Secondary elements are colored as in Fig. 2. b, Neu2
sugar-induced form in the same orientation as in a. The arrow
indicates the loop containing Glu111 that becomes ordered and
forms helix 2. c, Neu2-DANA complex
in the same orientation as in a. DANA is represented as a
ball-and-stick model. The arrows indicate two helices ( 1 and
2)
that are formed upon inhibitor binding.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2005,
280,
469-475)
copyright 2005.
2. c, Neu2-DANA complex
in the same orientation as in a. DANA is represented as a
ball-and-stick model. The arrows indicate two helices (