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Figure 4.
Figure 4
(a) Topology diagram of T. thermophilus DERA-substrate (DRP) interactions. The residues
and water molecules involved in the catalysis are coloured green. The substrate is shown
in red. Hydrogen bonds are indicated by dotted lines and lengths are given in Å. (b) The
substrate covalently bound to the pocket of the TIM-barrel strand [165][beta] 6. The
substrate and Lys151 residue are depicted in ball-and-stick representation. (c) The
electron density in the vicinity of the DERA active site with the carbinolamine-bound
model. The 2F[o] - F[c] electron density contoured at 2 [166][sigma] is shown in blue.
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