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Figure 4.
FIG. 4. a, ribbon model of bovine rhodopsin in blue with
phosphorylated C-terminal domain shown in yellow in
arrestin-bound conformation. Side chains of phosphorylated
serines and threonines are shown as ball-and-stick models.
Semi-transparent solvent-accessible surface of the phosphate
groups is shown in red. Position of the transmembrane helices of
rhodopsin is labeled. b, van der Waals surface of rhodopsin
(cytoplasmic side) as seen by arrestin with the electrostatic
potential mapped. White, neutral; red, negatively charged; blue,
positively charged. The phospho-groups on Ser-334, Thr-335,
Thr-336, Ser-338, Thr-340, Thr-342, and Ser-343 together with
carboxyl groups of Glu-332 and Glu-341 form a continuous
negatively charged surface. C2 and C3 show position of
cytoplasmic loops two and three.
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