Figure 4.
FIG. 4. Potency of -conotoxins at [1B]
expressed in the presence or absence of 3 and [2] . A,
potency estimates (K[d]) obtained from kinetic data in Tables I
and II. B, potency estimates obtained from
concentration-response curves at [1B-d] (n = 4-8 using
six batches of oocytes) produced similar results. Current
inhibition for [1B-d] + 3 or [1B-d] +
3 +
[2]
was
evaluated at 7 or 10 min after starting toxin perfusion,
respectively (see Fig. 5). Data indicated by the diamonds are
from two batches of oocytes showing an unusually high
sensitivity of [1B-d] + 3 to the
block by -conotoxin MVIIA (n =
4-7). Error bars show S.E.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2004,
279,
34705-34714)
copyright 2004.
-conotoxins at 
[1B]
expressed in the presence or absence of 
3 and 
. A,
potency estimates (K[d]) obtained from kinetic data in Tables I
and II. B, potency estimates obtained from
concentration-response curves at