Figure 4.
Figure 4. (A) MOLSCRIPT representation of the structure of
ICK toxins that act against K[V] channels. From left to right:
PaTx1 and HpTx2 (Kv4.2), HaTx1 (Kv2.1), -PVIIA
(shaker K+). (B) Sequence alignment of PaTx1 with other toxins
acting against K+ channels. PaTx1, PaTx2 (Phrixotoxins 1 and 2)
from Phrixotrichus auratus, HpTx2 (Heteropodatoxin 2) from
Heteropoda venatoria, HaTx1 (Hanatoxin 1) from Grammostola
spatulata, ScTx1 (Stromatoxin 1) from Stromatopelma calceata,
HmTx1 (Heteroscodratoxin 1) from Heteroscodra maculata, PVIIA (
-conotoxin
PVIIA) from Conus purpurascens (see references in text).
The above figure is reprinted
by permission from the Protein Society:
Protein Sci
(2004,
13,
1197-1208)
copyright 2004.
-PVIIA
(shaker K+). (B) Sequence alignment of PaTx1 with other toxins
acting against K+ channels. PaTx1, PaTx2 (Phrixotoxins 1 and 2)
from Phrixotrichus auratus, HpTx2 (Heteropodatoxin 2) from
Heteropoda venatoria, HaTx1 (Hanatoxin 1) from Grammostola
spatulata, ScTx1 (Stromatoxin 1) from Stromatopelma calceata,
HmTx1 (Heteroscodratoxin 1) from Heteroscodra maculata, PVIIA (