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Figure 4.
Figure 4. A large hydrophobic interface exists between
symmetry-related coiled coils. (a) The surface of the N terminus
of the coiled coil (NT-surface) (green and rose) contacts a
C-terminal surface of its symmetry-related neighbor (CT-surface)
(cyan and magenta). This interface, interface II, has a
hydrophobic core, seven ordered water molecules and a hydrogen
bonding network. For clarity, only hydrogen bonding involving
water molecules is shown. (b) Surface complementarity of
interface II. A coiled coil's NT-surface (molecular surface
representation) has a large hole into which Phe1322 from another
coiled coil's CT-surface nestles (cyan and magenta). Interface
residues from the CT-surface are shown. (c) and (d) Molecular
surfaces colored by hydrophobicity (F, V, I, L, A are yellow)
show the two interaction surfaces. A stick model is placed atop
the surface representation to indicate the position of the
interface. (c) The NT-surface. (d) The CT-surface.
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