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Figure 5.
Figure 5. Surface Representations Showing the Site III
Interfaces of LIF OSM, IL-6, and Viral IL-6The site III LIF and
OSM, which engage LIF receptor (LIFR) is defined by both a
conserved phenylalanine and a lysine residue. The structural
paradigm for site III has been established with hIL-6 (Boulanger
et al., 2003) and viral IL-6 (Chow et al., 2001), where the hot
spot residue is a single tryptophan that engages the Ig domain
of gp130.
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