Figure 4 - full size

 

Figure 4.
Figure 4. Binding of MetSA in the active site of MetRS. A, Schematic representation of the main electrostatic interactions between the enzyme and MetSA. Bottom: stereo views of active site-bound MetSA (B), Metol-AMP (C) and methionine plus adenosine (D). Only the enzyme residues relevant to the discussion in the text are drawn.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2003, 332, 59-72) copyright 2003.