Figure 4 - full size

 

Figure 4.
Figure 4. LIGPLOT[49.] describing interactions of the NADP+ molecule found in the structure of the ADH8-NADP+ complex. Only side-chains of residues Thr224, His225 and Lys228 interact with the terminal phosphate group of the NADP+ cofactor. Thr224 and His225 are sequence variations specific of ADH8 while Lys228 is conserved among NAD(H)-dependent ADHs (see in the text).

The above figure is reprinted by permission from Elsevier: J Mol Biol (2003, 330, 75-85) copyright 2003.