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Figure 4.
Figure 4. Electrostatic Potential Surface of Tdp1The
molecular surface is colored between −10kT (red) and +10kT
(blue) and was generated with the program GRASP [35]. The
orientation of the Tdp1 structure is the same as in Figure 1A.
The peptide-vanadate-DNA substrate mimic is displayed as a stick
structure. The yellow V indicates the position of the vanadate
residue in the active site. The DNA moiety extends above the
active site, bound in the narrow, positively charged half of the
substrate binding groove. The peptide moiety is located below
the active site in a relatively neutral portion of the wider
substrate binding cleft.
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