|
Figure 4.
Figure 4 Substrate/ligand(s) binding in the GluRS complexes. (A
-D) The GluRS catalytic site structures in the present complexes
are shown in the same orientation. The HVGT and KISKR motifs are
highlighted in purple. (A) The ERS/ATP/Glu structure. The
ATP-Mg2+ and glutamate molecules are shown in green. (B) The
ERS/ATP structure. The ATP-Mg2+ is colored light blue. (C) The
ERS/tRNA/ATP structure. The ATP molecule is colored salmon, and
the 3'-terminal adenosine (A76) of tRNA^Glu is cyan. (D) The
ERS/tRNA/GoA structure. The GoA (glutamol-AMP) molecule is
colored yellow. (E) A stereo view showing the ATP recognition in
ERS/tRNA/ATP. (F) A stereo view showing the GoA recognition in
ERS/tRNA/GoA.
|
