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Figure 4.
Figure 4. (a) A stereo view of the catalytic site showing
interactions between TTR and both AcCoA and the tightly bound
water molecule; GRASP surfaces showing the AcCoA-binding pocket
viewed from the front (b) and back (c), respectively (color
coded according to electrostatic potential: blue corresponds to
20k[B]T; white, 0k[B]T; and red, -20k[B]T). (b) The front view,
with two polar regions inside the hydrophobic-binding pocket.
The positive region indicated in blue corresponds to residue
Lys95 and the negative region in red corresponds to residues
Glu92 and Asp130. (c) The back view.
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