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Figure 4.
Figure 4 Discrimination of the first two first bases of the
ssDNA recognition site by KH domains of hnRNP K and FBP. (A)
hnRNP K KH3 recognizes TC, (B) FBP KH3 recognizes TT and (C) FBP
KH4 recognizes TA. The protein backbone and side chains are
shown in red and green, respectively, and the DNA in light blue.
The numbering scheme employed is that of the hnRNP K KH3−ssDNA
complex. Dashed lines indicate intermolecular hydrogen bonds.
The residue at position 25 plays a key role in selection of the
first two bases of the site. The coordinates of the FBP KH3/KH4
complex (accession code 1J4W) are taken from Braddock et al.
(2002).
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