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Figure 4.
Figure 4. Comparison of binding modes of the EVH1 domains.
A ribbon representation of the complex of the binding peptide
and the EVH1 domain, and ball-and-stick models of the binding
regions are shown. (a) and (b) The complex of the P-motif
(138-SPLTP-142) of PSD-Zip45 and the EVH1 domain analysed in
this study. (c) and (d) The complex of the proline-rich part
(1151-TPPSPF-1156) of mGluR and the EVH1 domain of Homer
1a.[16.] (e) and (f) The complex of the ActA peptide (1-FPPPP-5)
and the EVH1 domain of Mena. [14.] In (a), (c) and (e), all
binding peptides are indicated in red, and the EVH1 domains are
viewed from the same orientation. In the stereo pairs shown in
(b), (d) and (f), all binding peptides are indicated in red,
especially residues interacting with the EVH1 domain, which are
indicated in vivid red. Residues forming the EVH1 domain are
indicated in green, especially residues interacting with binding
peptides, which are indicated in vivid green. Residue labels
indicate the numbers for the binding peptide in Helvetica font,
and the numbers for the EVH1 domain in Times font. The Figure
was generated with MOLSCRIPT [36.] and Raster3D. [37.]
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