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Figure 4.
Figure 4. Conserved Water Structure(A) Fifty-two water
molecules that are conserved in at least four of the five
structures determined to 2.0 Å resolution and form at least two
protein-hydrogen bonds. Those waters found in both monomers are
labeled in bold, and only one of the two is labeled to improve
clarity. Equivalent clusters of waters are colored the same.
Those waters around the substrate peptide are shown in white
(Figure 2). Waters around the P1-loop and the tip of the flap
are shown in yellow.(B) On either side of the P1-loop, the
conserved waters are shown in blue (C) and red (D). Hydrogen
bonds between the protein and water are shown in bold, while
hydrogen bonds between nearby protein atoms are shown in dashed
lines.
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