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Figure 4.
Figure 4. Omit electron density for bound substrate and
product molecules contoured at 2.5s (stereo view). All complexes
were prepared by soaking. (a) Product complex with bound CMP and
2C-methyl- Image -erythritol 2,4-cyclodiphosphate (data set
Prod). (b) Substrate complex with bound
4-diphosphocytidyl-2C-methyl- Image -erythritol 2-phosphate and
zinc removed with EDTA; the green ball represents the zinc
position in the active enzyme (data set CDP-MEP). (c) Complex
with 4-diphosphocytidyl-2C-methyl- Image -erythritol (data set
CDP-ME). (d) Complex with MgCDP; the Mg ion bridges the a and
b-phosphate groups of CDP (data set MgCDP).
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