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Figure 4.
Figure 4. Stereo Representation of Ligands Bound in the
Active Site of b Image glucan GlucohydrolaseMOLSCRIPT [47]
diagrams of the nearest hydrogen bonding interactions (dashed
lines) between:(a) Glucose.(b) Cyclohexitol ring.(c)
2-deoxy-2-fluoro-a- Image -glucosyl moiety.(d) S-cellobioside
moiety.and the contact amino acid residues.Ligands are colored
in cyan. The molecular surfaces of domains 1 and 2 are
represented by transparent cyan and magenta surfaces,
respectively, and are generated using GRASP [48]. Black, red,
blue, yellow, and gray spheres represent carbon, oxygen,
nitrogen, sulfur, and fluorine atoms, respectively. Water
molecules are represented as red spheres. In (c), residues E220,
E287, R291, and E491, along with Wat2 and Wat3, are not
included, to improve the clarity of the data. The entrance to
the active site in (b) and (c) is located perpendicularly to the
page and is located toward the lower left hand corner in (a) and
(d)
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