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Figure 4.
Figure 4: Relative position of chloramphenicol, clindamycin and
macrolides with respect to CC-puromycin and the
3'-cytosine-adenine (CA) end of P-site and A-site tRNAs. The
location of CC-puromycin was obtained by docking the position
reported by ref. 2 into the peptidyl transferase centre of D.
radiodurans. The location of the 3'-CA end of P- and A-site
tRNAs was obtained by docking the position reported by ref. 42
into the peptidyl transferase centre of D. radiodurans. Light
blue, 3'-CA end of A-site tRNA; light yellow, 3'-CA end of
P-site tRNA; grey, puromycin; gold, chloramphenicol; green,
clindamycin; cyan, macrolides (erythromycin). Oxygen atoms are
shown in red and nitrogen atoms in dark blue. CHCl[2] indicates
the location of the dichloromethyl moiety of chloramphenicol.
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