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Figure 4.
Figure 4 The structure of IL-17F. (A) Ribbon trace of the IL-17F
monomer. Strands are labeled. Disulfides are shown as
ball-and-stick representation with the sulfur atoms colored
yellow. Glycosylation of Asn53 is indicated by a purple ball.
Inset shows a cartoon representation of the canonical cystine
knot fold. Cysteine residues are indicated by filled circles;
those present in IL-17 proteins are yellow, whereas the two that
are missing are black. (B) Ribbon trace of the IL-17F dimer.
Disulfides are shown as in (A). (C) The structure of NGF from
the NGF -TrkA complex (Wiesmann et al., 1999; Protein Data Bank
code 1WWW); a disordered loop connects strands 2 and 3.
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