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Figure 4.
Fig. 4. Asymmetry of the hormone/receptor interfaces and the
conformation of CNP. (A) Stick representation of the bound CNP
peptide (orange) and the interacting amino acids from each NPR-C
monomer (cyan and green) (40). The yellow spheres represent the
bound chloride ions in each monomer. Ile^188, which has been
shown to modulate the ligand pharmacology of NPR-C (37), is next
to the CNP residue Phe^7, and is labeled in black. (B) This
interface is then shown in an "open-book" view of the molecular
surface of each receptor monomer. The CNP peptide is shown as a
yellow backbone-and-stick model projected onto the respective
buried surfaces (red patches) of each NPR-C monomer. The figures
were drawn with BOBSCRIPT, RASTER3D, and VMD (41).
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