Figure 4 - full size

 

Figure 4.
Figure 4 Stereo diagram of a contact region for the trigonal form in the wild type (blue) and the EL(L205) mutant (red). In the wild type, GluL205 interacts with HisH68, which is part of a loop formed by residues H68-H74 that is close to the same loop of a symmetry-related protein. This contact interaction is mediated by water molecules (blue) associated with ThrH72 and ThrH74. The substitution of Leu for Glu at L205 results in the association of a molecule, probably an ion (red), near L205 and H68 and loss of the bridging water molecules.

The above figure is reprinted by permission from the IUCr: Acta Crystallogr D Biol Crystallogr (2001, 57, 1281-1286) copyright 2001.