Figure 4 - full size

Figure 4. Figure 4. The Conformation of pCDK2 in the pCDK2/KAPt Complex Represents the Activated ConformationA structural comparison of CDK2 as the nonphosphorylated monomer in the pCDK2/cyclin A complex and in the pCDK2/KAPt complex. Except for differences in the conformation of the activation segment residues 152–165, the conformation of CDK2 in the pCDK2/cyclin A binary complex is most similar to the pCDK2/KAPt structure. The N- and C-terminal lobes of CDK2 are colored white and gold, respectively, and the C helix is shown in magenta. The activation segment is green, except for residues 153–164 that are disordered in monomeric pCDK2 and are shown in red

The above figure is reprinted by permission from Cell Press: Mol Cell (2001, 7, 615-626) copyright 2001.