Figure 4.
Fig. 4. Details of halothane binding sites. A, halothane
binding sites at the interface between subdomains IIA and IIB.
B, halothane site in subdomain IIIA. C, halothane sites in
subdomain IIA. D, halothane site at the interface between
subdomains IA and IIA. The difference electron density is an
F[o] F[c] omit
map calculated at 4 . Some of
the amino acid side chains that are close to the halothane
molecules are shown as ball and stick models (a complete list is
given in Table IV). Note that in D only 11 of the 14 carbon
atoms of myristate are shown because, due to disorder, the
terminal carbons were not observed in the electron density map.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2000,
275,
38731-38738)
copyright 2000.
F[c] omit
map calculated at 4 
. Some of
the amino acid side chains that are close to the halothane
molecules are shown as ball and stick models (a complete list is
given in Table IV). Note that in D only 11 of the 14 carbon
atoms of myristate are shown because, due to disorder, the
terminal carbons were not observed in the electron density map.