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Figure 4.
Fig. 4. Evolution of sesquiterpene biosynthetic pathways.
Structural comparison of terpenoid synthases reveals that each
enzyme in the biosynthetic pathway is a variation of the
"terpenoid synthase fold," despite insignificant amino acid
sequence identities. This structural comparison indicates
evolutionary divergence of animal, plant, bacterial, and fungal
cyclases from a common primordial ancestor.
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