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Figure 4.
Figure 4. Model for nNOS signal transduction complex
organization by PDZ domains. The NMDA receptors are clustered
by multiple PDZ domain containing PSD-95. The multimeric PSD-95
further couples nNOS to the NMDA receptors, allowing direct
activation of nNOS by influxes of Ca^2+. The PDZ domain of nNOS
can further recruit its binding protein such as CAPON by binding
to its C-terminal tail. The PTB domain of CAPON may bind to as
yet unknown NPXpY motif containing proteins in the signaling
pathway.
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