Figure 5 - full size

 

Figure 5.
Figure 5. The Serotonin Binding Site Is Buried in the Protein Interior(A) Hydrophobic residues lining the funnel. For clarity, only the acetyl and β-mercaptoethyl groups of AcCoA are shown modeled in the active site.(B) View into the hydrophobic funnel looking down toward ND1 of His-122 (in blue); the surrounding hydrophobic residues are shown in white. Figure was created by PovChem (P. Thiessen, Chem. Dept., School of Chemical Sciences, U. of Illinois at Urbana-Champaign), a front end for POV-Ray 3.0.

The above figure is reprinted by permission from Cell Press: Mol Cell (1999, 3, 23-32) copyright 1999.