Figure 3.
Figure 3 T1 side chains and views of layers 1, 2 and 3. a,
Side chains conserved in all four subfamilies of voltage-gated
potassium channels (those in black boxes in Fig. 1b). The
backbone of the T1 subunit is shown as a ribbon. Subdomain A is
inblue, the variable region between subdomains A and B is in
red, and subdomain B is in green. b, Side chains of 15 residues
involved in polar intersubunit interactions (E 78, T 79, Q 80, T
83, D 119, Q 126, R 130 and R 132 from subunit 1; N 71', S 73',
R 76', D 112', R 115', D 140' and E 144' from subunit 2). Only
side chain-side chain interactions are shown. Underlined
residues are conserved in all Shaker subfamily members. c-e,
Cross-sectional views of layers 1 (c), 2 (d) and 3 (e). C backbone
atoms of the T1 tetramer in the three crystal forms (I in blue,
C in green and P in red) are superimposed. Based on all
main-chain atoms, the root mean square deviations are 0.92 Å
between the P and C forms, 0.84 Å between the I and C forms, and
0.77 Å between the I and P forms. The most significant
differences occur within the region between R 133 and D 140
(r.m.s. deviations between 1.25 and 2.1 Å).
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(1998,
392,
945-948)
copyright 1998.
backbone
atoms of the T1 tetramer in the three crystal forms (I in blue,
C in green and P in red) are superimposed. Based on all
main-chain atoms, the root mean square deviations are 0.92 Å
between the P and C forms, 0.84 Å between the I and C forms, and
0.77 Å between the I and P forms. The most significant
differences occur within the region between R 133 and D 140
(r.m.s. deviations between 1.25 and 2.1 Å).