|
Figure 3.
Structure of VEGFR2 D7 homodimer. (A) A ribbon diagram and a
transparent molecular surface of D7 homodimer structure (side
view). Asp731 and Arg726 are shown as a stick model. (B) A close
view of the homotypic D7 interface of the two neighboring
molecules (pink and green). Salt bridges formed between Asp731
and Arg726 are shown as dashed lines. (C) Charge distribution of
D7 homodimer (side view) is shown as a surface potential model
(Left). View of D7 surface that mediates homotypic contacts
(Right). (D) 2F[o]-F[c] electron density map contoured at 1.1σ
level showing a view of the D7–D7 interface. The backbones of
VEGFR D7 protomers are represented as pink and yellow tubes,
respectively.
|
