Figure 3 - full size

 

Figure 3.
The cathepsin V-clitocypin complex. A, shown is the view along the active site cleft. B, shown is the view perpendicular to the active site cleft. The folds of cathepsin V and clitocypin are shown in gray and red. The catalytic cysteine is shown in yellow. Clitocypin binds into the active site of cathepsin V in the orientation of a fallen tree with the trunk and roots pointing sideways and up. The wedge shaped structure fills the active site cleft along its whole length.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2009, 285, 308-316) copyright 2009.