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Figure 3.
Figure 3. Structural Comparison between Unglycosylated and
Glycosylated IL-7/IL-7Rα Complexes
(A) Superimposition of
the unglycosylated structures (wheat and blue) onto the
glycosylated structure (green) using the D1 and D2 domains of
the receptors.
(B) Molecular surface view of IL-7 and
IL-7Rα highlighting the hydrophobic (orange) and hydrophilic
(lime green) residues in the binding interface.
(C and D)
Bar graphs showing the amount of buried surface area for IL-7
(C) and IL-7Rα (D) in the unglycosylated (red bars) and
glycosylated (blue bars) complexes. Secondary structure
locations are labeled below the residues.
(E) Two views of
the intermolecular interactions observed between the
IL-7/IL-7Rα unglycosylated (wheat) and glycosylated (green)
structures. H bonds are depicted as dashes colored black and
green for the unglycosylated and glycosylated complexes,
respectively.
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