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Figure 3.
(a) Structure of the C-terminal E3 ligase domain of IpaH3.
Secondary structures are marked with numbered labels, and broken
lines indicate disordered loop regions. Cys363 and Asp365, which
are important for catalyzing ubiquitin transfer, are highlighted
in yellow and shown in sticks. (b) Representative structures of
RING-finger and U-box E3 ligases. The RING-finger and U-box
domains were selected from RING-type E3 ligase Cbl (PDB 1FBV)
and U-box E3 ligase Ufd2p (PDB 2QIZ), respectively. The zinc
ions in Cbl are colored orange. (c) Structure of the HECT domain
of E6AP (PDB 1D5F). The N and C lobes are colored red and
purple, respectively. The catalytic cysteine (Cys820) and the
hinge loop connecting the two lobes are indicated.
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