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Figure 3.
Polymorphic sites of PAF-AH shown in gray ball and stick
relative to the active site Ser^273 and in a view looking
directly at the interfacial binding surface of the enzyme. Three
of the polymorphic sites (I198T, A379V, and R92H) are
solvent-accessible. Two loss of function polymorphisms (V279F
and Q281R) that lead to a loss of function in 4% of Japanese
individuals are core residues. This figure was rendered using
the program PyMOL (51).
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