Figure 3.
Superposition of the backbones of AurA/TPX2/VX-680 (gold) and
AurA/TPX2/ADP (gray, pdb: 1ol5) structures focusing on the
different conformations of the glycine-rich loop. The C[alpha]
of Phe144^AUR in the AurA/TPX2/VX-680 structure has moved by >8
A. The VX-680 carbons are in yellow, the ADP carbons in green,
oxygens in red, nitrogens in blue, sulfur and phosphorus in
orange. The side chain of Phe144 is shown in stick form.
The above figure is reprinted
from an Open Access publication published by the Protein Society:
Protein Sci
(2008,
17,
1791-1797)
copyright 2008.
