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Figure 3.
X-ray crystal structure of cDPCP-modified DNA. (A) Schematic
diagram showing the DNA sequence and location of the platinum
adduct for the complex studied by x-ray crystallography. (B)
Structure of the cDPCP-damaged DNA duplex, which maintains a
linear B-form conformation despite binding of the Pt complex.
(C) Close-up view of the monofunctional Pt–dG adduct, with
2F[o]−F[c] maps contoured at 1σ (blue) and 15σ (green),
which show significant electron density around the platinum
atom. (D) The platinated base pair (blue) overlaid with ideal
B-form DNA (gray). Platinum-binding forces the DNA bases out
into the major groove.
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