Figure 3.
FIGURE 3. A gallery of SCAF8-CID binding to different
phospho forms of the CTD. SCAF8-CID is shown as a ribbon
representation; the CTD is shown as a stick model. Hydrogen
bonds between SCAF8-CID and the CTD are illustrated as black
dashed lines, and intramolecular hydrogen bonds within the
β-turn of the CTD are in orange. 2F[o] - F[c] electron density
contoured at 0.9 for the bound
CTD-peptides is illustrated beneath each model. Shown is
SCAF8-CID binding Ser(P)-2/Ser(P)-5-CTD (PDB code 3D9K) (A),
Ser(P)-2-CTD (PDB code 3D9L) (B), Ser(P)-5-CTD (PDB code 3D9M)
(C), unphosphorylated CTD (PDB code 3D9O) (D), and
Ser(P)-2/Ser(P)-7-CTD (PDB code 3D9N) (E) and Pcf11-CID (PDB
code 1SZA) binding Ser(P)-2-CTD (F).
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2008,
283,
22659-22669)
copyright 2008.
for the bound
CTD-peptides is illustrated beneath each model. Shown is
SCAF8-CID binding Ser(P)-2/Ser(P)-5-CTD (PDB code 3D9K) (A),
Ser(P)-2-CTD (PDB code 3D9L) (B), Ser(P)-5-CTD (PDB code 3D9M)
(C), unphosphorylated CTD (PDB code 3D9O) (D), and
Ser(P)-2/Ser(P)-7-CTD (PDB code 3D9N) (E) and Pcf11-CID (PDB
code 1SZA) binding Ser(P)-2-CTD (F).