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Figure 3.
Figure 3. Organization of the CH Domains in the Ndc80-Nuf2
Subcomplex
(A) Topology diagram of Ndc80 and Nuf2. The CH
domain is contained between the αA and αG helices.
(B)
Two views of the superposition of the CH domains of Ndc80 and
Nuf2. Note the conspicuous bending of the tips of the Nuf2 αE
helix.
(C) Structure-based sequence alignment of the CH
domains of Ndc80, Nuf2, and EB1. The αA, αC, αE, and αG
helices are contoured. Residues highlighted in gray have their
side chains buried in the hydrophobic core of the CH domain.
(D) General view and closeups of the interface of Ndc80 and
Nuf2.
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