Figure 3.
Figure 3: Structure of CDCA1-R2 bound to substrate analogue
acetate. a, A close-up view of the region around acetate. The
F[o] - F[c] electron density map surrounding acetate was
calculated using simulated annealing with the omission of
acetate and was contoured at 5 .
b, A close-up view of the active site conformation. Metal
coordination and hydrogen bonds are indicated by red and green
dashed lines, respectively. Relevant distances are indicated
(Å). c, A hydrophobic channel traverses through CDCA1-R2.
Cd is highlighted in red. Acetate is shown in yellow. The
conserved hydrophobic residues that line the channel are shown
in magenta. (Stereo views of a and b are shown in Supplementary
Fig.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2008,
452,
56-61)
copyright 2008.
.
b, A close-up view of the active site conformation. Metal
coordination and hydrogen bonds are indicated by red and green
dashed lines, respectively. Relevant distances are indicated
(Å). c, A hydrophobic channel traverses through CDCA1-R2.
Cd is highlighted in red. Acetate is shown in yellow. The
conserved hydrophobic residues that line the channel are shown
in magenta. (Stereo views of a and b are shown in Supplementary
Fig.