Figure 3.
Fig. 3. (A) Aryl–OCHF[2] fragment ( = 19°) of
roflumilast bound to phosphordiesterase 4 (table S1, entry 7)
shows a multipolar C–F···C=O contact with
the backbone amide of Trp332. (B) Aryl–OCF[3] fragment ( =
81°) of an inhibitor bound to the Ser protease trypsin
(table S1, entry 13). Protein Cs are shown in gray (also applies
to Fig. 5 and the SOM).
The above figure is reprinted
by permission from the AAAs:
Science
(2007,
317,
1881-1886)
copyright 2007.
= 19°) of
roflumilast bound to phosphordiesterase 4 (table S1, entry 7)
shows a multipolar C–F···C=O contact with
the backbone amide of Trp332. (B) Aryl–OCF[3] fragment (