Figure 3.
Figure 3: Structure of the ligand-binding site in S. cerevisiae
Snf4. Stereo-view overlay of the structures of the -subunits
of S. cerevisiae SNF1 (Snf4, in green) and S. pombe AMPK (in
grey)^9. The position of AMP is observed in the S. pombe
structure^9, as well as from our studies. Residues that could
interact with AMP are shown, and those that are equivalent to
disease-causing mutations in mammalian -subunits
are labelled in red. Produced with Ribbons^30.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2007,
449,
492-495)
copyright 2007.
-subunits
of S. cerevisiae SNF1 (Snf4, in green) and S. pombe AMPK (in
grey)^9. The position of AMP is observed in the S. pombe
structure^9, as well as from our studies. Residues that could
interact with AMP are shown, and those that are equivalent to
disease-causing mutations in mammalian