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Figure 3.
Figure 3. Comparison of the FMN-binding site in the dark
state structures of (a) YtvA-LOV, (b) Chlamydomonas phot1 LOV1
and (c) Adiantum phy3 LOV2. Carbon atoms are shown in black,
nitrogen atoms in blue, oxygen atoms in red, sulfur in yellow
and phosphorus in magenta. Water molecules are depicted as red
spheres. Broken green lines indicate hydrogen bonds or
salt-bridges. The hydrogen bond network coordinating the FMN
ring is highly conserved between the various LOV domains,
whereas there is some variability in the hydrophobic residues
lining the flavin ring. The key cysteine residue may adopt two
conformations in the dark state, denoted a and b.
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