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Figure 3.
Fig. 3. Phylogenetic topology of structurally characterized
enzymes functionally and/or structurally related to RdxR. (A)
FNR, plant-type ferredoxin reductase; AdxR, adrenodoxin
reductase; AIF, apoptosis inducing factor; LpdR, lipoamide
reductase; TptR, trypanothione reductase. Sequence identity to
RdxR is indicated by percentage. (B) Superposition of
uncomplexed (gray) and complexed RdxR (colored as in Fig. 1A).
Cofactors are shown as ball-and-stick models. For clarity, the
position of Rdx is indicated by a brown sphere. (C) Comparison
of the Rdx (red) and Trx (black) binding sites of RdxR and TrxR.
For clarity, only the molecular surface of RdxR is shown.  G^0
optimized ET rates (42) between FAD and each point of the RdxR
surface are indicated by a color gradient (red, high ET rate;
green, medium; blue, low). (Inset) Close-up view of the
cofactors involved.
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