Figure 3.
Fig. 3. Agonist recognition by mGluR-II[3]. Schematic
drawings for the binding of Glu (A), DCG-IV (B), 1S,3S-ACPD (C),
1S,3R-ACPD (D), and 2R,4R-APDC (E). Hydrogen atoms attached at
the C[ ]atom of the ligands
are modeled with the corresponding ideal geometries. Only the
residues/water molecules that directly interact with one of the
agonists are drawn. Red and blue lines indicate hydrogen-bonding
and VDW contact, respectively. Either of the two carboxyl oxygen
atoms connected by the green line in B is likely to be
protonated, as suggested from the short distance between them
(2.4 Å).
]atom of the ligands
are modeled with the corresponding ideal geometries. Only the
residues/water molecules that directly interact with one of the
agonists are drawn. Red and blue lines indicate hydrogen-bonding
and VDW contact, respectively. Either of the two carboxyl oxygen
atoms connected by the green line in B is likely to be
protonated, as suggested from the short distance between them
(2.4 Å).