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Figure 3.
FIGURE 3. Divalent ion binding site in WNV POL. Stereo view
of the calcium/magnesium ion non-catalytic binding site. The
POL2 model is represented in green sticks and the corresponding
electronic density in blue. The Ca^2+ ion is shown as a green
sphere. The figure is centered on the aspartic acids of motifs A
and C colored in yellow. Coordination with Asp^536 (motif A) and
Asp^669 (motif C) are indicated by black dotted lines.
Corresponding aspartic acids of motifs A and C in Phi6 (Asp^324,
Asp^453, and Asp^454) (PDB code 1HI0) are represented in magenta
sticks. The position of the two ions in the catalytic position,
inferred from the Phi6 RdRp structure, is indicated in purple.
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