Figure 3.
Figure 3 Detailed view of the PTP -CD
active site. (a) Hydrogen-bonding network (blue dashes) bridging
the ligand (vanadate ion, balls-and-stick representation) and
the protein (sticks). (b) Side view depicting additional
interactions (magenta dashes) between the ligand and polar
residues in the active site. The partial covalent bond between
Cys1904 and the V atom is shown as an orange dashed line. (c)
Side view of a pTyr mimetic (p-ethyl phenylsulfamic acid) bound
in the active site of the enzyme. Relevant hydrogen bonds are
shown as colored dashes.
The above figure is reprinted
by permission from the IUCr:
Acta Crystallogr D Biol Crystallogr
(2006,
62,
1435-1445)
copyright 2006.
-CD
active site. (a) Hydrogen-bonding network (blue dashes) bridging
the ligand (vanadate ion, balls-and-stick representation) and
the protein (sticks). (b) Side view depicting additional
interactions (magenta dashes) between the ligand and polar
residues in the active site. The partial covalent bond between
Cys1904 and the V atom is shown as an orange dashed line. (c)
Side view of a pTyr mimetic (p-ethyl phenylsulfamic acid) bound
in the active site of the enzyme. Relevant hydrogen bonds are
shown as colored dashes.