Figure 3.
Figure 3: Transmission interface. Figure 3 :
Transmission interface. Unfortunately we are unable to
provide accessible alternative text for this. If you
require assistance to access this image, or to obtain a
text description, please contact npg@nature.com-
a, Close-up view of Sav1866 with one subunit in turquoise
ribbon representation, the other in yellow coil representation.
For clarity, only the ICL regions of the transmembrane domains
are shown. Black spheres depict the first and last C positions
of the 'coupling helices' (see the text). Side chains of
the conserved Glu 473 and Tyr 391 are in ball-and-stick
representation. b, Alignment of the Sav1866 protein sequence
with those of other ABC transporters. Residues with high
conservation are shaded dark grey, those with significant
conservation are shaded light grey, and relevant motifs are
shaded blue and indicated. Residues of the ICLs interacting (4
Å cut-off) with the NBD of the same subunit are indicated
with green shading, and those contacting the opposite NBD with
yellow shading. Residues of the NBD interacting with the TMD are
shown with red shading.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2006,
443,
180-185)
copyright 2006.
positions
of the 'coupling helices' (see the text). Side chains of
the conserved Glu 473 and Tyr 391 are in ball-and-stick
representation. b, Alignment of the Sav1866 protein sequence
with those of other ABC transporters. Residues with high
conservation are shaded dark grey, those with significant
conservation are shaded light grey, and relevant motifs are
shaded blue and indicated. Residues of the ICLs interacting (4
Å cut-off) with the NBD of the same subunit are indicated
with green shading, and those contacting the opposite NBD with
yellow shading. Residues of the NBD interacting with the TMD are
shown with red shading.