Figure 3.
Figure 3: Oseltamivir binding to the active sites of group-1
neuraminidases. a, Superposition of the active sites of N8
after a 30-min soak (dark blue) and a 3-day soak (cyan) with 20
M
oseltamivir. There are small changes in the position of Glu 119
and the inhibitor when the 150-loop closes after the longer
soaking time. b, Superposition of the active sites of N8 with
bound oseltamivir after the 3-day soak with 20 M
inhibitor (cyan) with N1 soaked for 30 min in 0.5 mM inhibitor
(green). In this case, the structures of the two different
subtypes of neuraminidase from group-1 are remarkably similar.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2006,
443,
45-49)
copyright 2006.
M
oseltamivir. There are small changes in the position of Glu 119
and the inhibitor when the 150-loop closes after the longer
soaking time. b, Superposition of the active sites of N8 with
bound oseltamivir after the 3-day soak with 20